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1

Formation of Pyroglutamic Acid from N-Terminal Glutamic Acid in Immunoglobulin Gamma Antibodies

Chelius, Dirk, Jing, Kay, Lueras, Alexis, Rehder, Douglas S., Dillon, Thomas M., Vizel, Alona, Rajan, Rahul S., Li, Tiansheng, Treuheit, Michael J., Bondarenko, Pavel V.

Journal:

Analytical Chemistry

Year:

2006

Language:

english

File:

PDF, 159 KB

english, 2006

2

O-Fucosylation of an antibody light chain: Characterization of a modification occurring on an IgG1 molecule

Valliere-Douglass, J. F, Brady, L. J, Farnsworth, C., Pace, D., Balland, A., Wallace, A., Wang, W., Treuheit, M. J, Yan, B.

Journal:

Year:

2008

Language:

english

File:

PDF, 668 KB

english, 2008

3

Kultursoziologische Erforschungder Welt- Und Lebensanschauung

Treuheit, Klaus

Journal:

European Journal of Sociology

Year:

1985

Language:

german

File:

PDF, 748 KB

german, 1985

4

High-Throughput Screening and Analysis of Charge Variants of Monoclonal Antibodies in Multiple Formulations

Alekseychyk, Larysa, Su, Cheng, Becker, Gerald W., Treuheit, Michael J., Razinkov, Vladimir I.

Journal:

Year:

2017

Language:

english

File:

PDF, 973 KB

english, 2017

5

LC/MS analysis of complex multiglycosylated human α1-acid glycoprotein as a model for developing identification and quantitation methods for intact glycopeptide analysis

Melanie M. Ivancic, Himanshu S. Gadgil, H. Brian Halsall, Michael J. Treuheit

Journal:

Analytical Biochemistry

Year:

2010

Language:

english

File:

PDF, 599 KB

english, 2010

6

Neurologische Erkankungen – Pathophysiologie, Diagnostik und Therapie neuromuskulärer Erkrankungen

Year:

2010

Language:

german

File:

PDF, 825 KB

german, 2010

7

The LC/MS analysis of glycation of IgG molecules in sucrose containing formulations

Himanshu S. Gadgil, Pavel V. Bondarenko, Gary Pipes, Doug Rehder, Arnold McAuley, Natalie Perico, Tom Dillon, Margaret Ricci, Michael Treuheit

Journal:

Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 487 KB

english, 2007

8

Formulation of Neulasta® (pegfilgrastim)

Deirdre Murphy Piedmonte, Michael J. Treuheit

Journal:

Advanced Drug Delivery Reviews

Year:

2008

Language:

english

File:

PDF, 280 KB

english, 2008

9

Sodium Chloride Enhances the Storage and Conformational Stability of BDNF and PEG-BDNF

William J. Callahan, Linda O. Narhi, Andrew A. Kosky, Michael J. Treuheit

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 227 KB

english, 2001

10

Receptor-binding hydrogenâdeuterium exchange mass spectrometry as an additional measurement of biosimilarity

Treuheit, Nicholas A., Crawford, Nicholas F., Maki, Steven, Payne, Jason, Allen, Jeff

Journal:

Journal of Pharmaceutical Investigation

Year:

2020

Language:

english

File:

PDF, 2.57 MB

english, 2020

11

Serum Concentration of Chlormethiazole and Therapeutic Effect in Acute Alcohol Withdrawal Syndrome: An Open Clinical Trial

Ulrich, Sven, Danos, Peter, Baumann, Bruno, Müller, Dörthe, Lehmann, Dörthe, Treuheit, Tim-Oliver, Spieler, Marion

Journal:

Therapeutic Drug Monitoring

Year:

2002

Language:

english

File:

PDF, 486 KB

english, 2002

12

Current perspectives on biosimilars

Agbogbo, Frank K., Ecker, Dawn M., Farrand, Allison, Han, Kevin, Khoury, Antoine, Martin, Aaron, McCool, Jesse, Rasche, Ulrike, Rau, Tiffany D., Schmidt, David, Sha, Ma, Treuheit, Nicholas

Journal:

Journal of Industrial Microbiology & Biotechnology

Year:

2019

Language:

english

File:

PDF, 1.93 MB

english, 2019

13

Middle-down fragmentation for the identification and quantitation of site-specific methionine oxidation in an IgG1 molecule

Gary D. Pipes, Phillip Campbell, Pavel V. Bondarenko, Bruce A. Kerwin, Michael J. Treuheit, Himanshu S. Gadgil

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 391 KB

english, 2010

14

Optimization and Applications of CDAP Labeling for the Assignment of Cysteines

Gary D. Pipes, Andrew A. Kosky, Jeffrey Abel, Yu Zhang, Michael J. Treuheit, Gerd R. Kleemann

Journal:

Pharmaceutical Research

Year:

2005

Language:

english

File:

PDF, 559 KB

english, 2005

15

HPLC of individual site glycoforms in serum orosomucoid

M. Treuheit, H. B. Halsall

Journal:

Chromatographia

Year:

1991

Language:

english

File:

PDF, 248 KB

english, 1991

16

Purification of the glycosylated beta subunit of (Na,K)-ATPase by lectin affinity chromatography

M. J. Treuheit, A. Ataei, T. L. Kirley, E. T. Wallick

Journal:

Chromatographia

Year:

1992

Language:

english

File:

PDF, 502 KB

english, 1992

17

Disease-coupled specificity in the glycan structures of orosomucoid

Michael J. Treuheit, H.Brian Halsall

Journal:

Clinica Chimica Acta

Year:

1992

Language:

english

File:

PDF, 174 KB

english, 1992

18

Characterization and Stability ofN-terminally PEGylated rhG-CSF

Olaf B. Kinstler, David N. Brems, Scott L. Lauren, Amiee G. Paige, James B. Hamburger, Michael J. Treuheit

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 1.23 MB

1996

19

Inactivation of the Na,K-ATPase by modification of Lys-501 with 4-acetamido-4′-isothiocyanatostilbene-2,2′-disulfonic acid (SITS)

Carlos H. Pedemonte, Torence L. Kirley, Michael J. Treuheit, Jack H. Kaplan

Journal:

Year:

1992

Language:

english

File:

PDF, 392 KB

english, 1992

20

Removal of the fluorescent 4-(aminosulfonyl)-2,1,3-benzoxadiazole label from cysteine-containing peptides

Scott L Lauren, Michael J Treuheit

Journal:

Journal of Chromatography A

Year:

1998

Language:

english

File:

PDF, 136 KB

english, 1998

21

PEGylation Prevents the N-Terminal Degradation of Megakaryocyte Growth and Development Factor

Patricia I. Guerra, Christine Acklin, Andrew A. Kosky, Janice M. Davis, Michael J. Treuheit, David N. Brems

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 513 KB

1998

22

Site-Specific Conjugation of Diethylenetriaminepentaacetic Acid to Recombinant Human Granulocyte-Colony-Stimulating Factor: Preservation of Protein Structure and Function

Ralph, Lloyd D., Ransone, Charles M., Treuheit, Michael, Lauren, Scott, Katta, Viswanatham, Litzinger, David C.

Journal:

Year:

1995

Language:

english

File:

PDF, 2.00 MB

english, 1995

23

Automated tryptic digestion procedure for HPLC/MS/MS peptide mapping of immunoglobulin gamma antibodies in pharmaceutics

Dirk Chelius, Gang Xiao, Andrew C. Nichols, Alona Vizel, Bing He, Thomas M. Dillon, Douglas S. Rehder, Gary D. Pipes, Edmund Kraft, Asha Oroska, Michael J. Treuheit, Pavel V. Bondarenko

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2008

Language:

english

File:

PDF, 1.24 MB

english, 2008

24

Resolving Liquid-Liquid Phase Separation for a Peptide Fused Monoclonal Antibody by Formulation Optimization

Qi, Wei, Alekseychyk, Larysa, Nuanmanee, Noi, Temel, Deniz B., Jann, Victoria, Treuheit, Mike, Razinkov, Vladimir

Journal:

Journal of Pharmaceutical Sciences

Year:

2020

File:

PDF, 1.40 MB

2020

25

Reversed-phase liquid chromatography–mass spectrometry of site-specific chemical modifications in intact immunoglobulin molecules and their fragments

Da Ren, Gary Pipes, Gang Xiao, Gerd R. Kleemann, Pavel V. Bondarenko, Michael J. Treuheit, Himanshu S. Gadgil

Journal:

Journal of Chromatography A

Year:

2008

Language:

english

File:

PDF, 213 KB

english, 2008

26

An improved trypsin digestion method minimizes digestion-induced modifications on proteins

Da Ren, Gary D. Pipes, Dingjiang Liu, Liang-Yu Shih, Andrew C. Nichols, Michael J. Treuheit, David N. Brems, Pavel V. Bondarenko

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 555 KB

english, 2009

27

Thermodynamic Compensation upon Binding to Exosite 1 and the Active Site of Thrombin

Treuheit, Nicholas A., Beach, Muneera A., Komives, Elizabeth A.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.99 MB

english, 2011

28

Misoprostol as a Therapeutic Option for Trigeminal Neuralgia in Patients with Multiple Sclerosis

GISELHER PFAU, MICHAEL BRINKERS, TIM TREUHEIT, MORITZ KRETZSCHMAR, MERT SENTüRK, THOMAS HACHENBERG

Journal:

Year:

2012

Language:

english

File:

PDF, 129 KB

english, 2012

29

Optimized UV Detection of High-Concentration Antibody Formulations using High-Throughput SE-HPLC

Molloy, Shabnam, Fesinmeyer, R. Mathew, Martinez, Theresa, Murphy, Piedmonte D., Pelletier, Mary E., Treuheit, Michael J., Kleemann, Gerd R.

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 2.14 MB

english, 2015

30

Optimized UV Detection of High-Concentration Antibody Formulations using High-Throughput SE-HPLC. 2015. J Pharm Sci 104:508–514

Molloy, Shabnam, Fesinmeyer, R. Matthew, Martinez, Theresa, Piedmonte, Deirdre Murphy, Huff Pelletier, Mary E., Treuheit, Michael J., Kleemann, Gerd R.

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

File:

PDF, 33 KB

2015

31

Reversed-phase liquid chromatography of immunoglobulin G molecules and their fragments with the diphenyl column

Da Ren, Gary D. Pipes, David M. Hambly, Pavel V. Bondarenko, Michael J. Treuheit, David N. Brems, Himanshu S. Gadgil

Journal:

Journal of Chromatography A

Year:

2007

Language:

english

File:

PDF, 559 KB

english, 2007

32

Improving Mass Accuracy of High Performance Liquid Chromatography/Electrospray Ionization Time-of-Flight Mass Spectrometry of Intact Antibodies

Himanshu S. Gadgil, Gary D. Pipes, Thomas M. Dillon, Michael J. Treuheit, Pavel V. Bondarenko

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2006

Language:

english

File:

PDF, 268 KB

english, 2006

33

The glycan patterns at the individual glycosylation sites in orosomucoid from allergic reaction patients

M. J. Treuheit, H. B. Halsall

Journal:

Chromatographia

Year:

1993

Language:

english

File:

PDF, 274 KB

english, 1993

34

Sustained in vivo activity of recombinant human granulocyte colony stimulating factor (rHG-CSF) incorporated into hyaluronan

James Meyer, Lane Whitcomb, Michael Treuheit, David Collins

Journal:

Journal of Controlled Release

Year:

1995

Language:

english

File:

PDF, 407 KB

english, 1995

35

The effects of alpha-helix on the stability of Asn residues: Deamidation rates in peptides of varying helicity

Andrew A. Kosky, Ursula O. Razzaq, Michael J. Treuheit, David N. Brems

Journal:

Protein Science

Year:

1999

Language:

english

File:

PDF, 191 KB

english, 1999

36

Accelerated Formulation Development of Monoclonal Antibodies (mAbs) and mAb-Based Modalities: Review of Methods and Tools

Razinkov, V. I., Treuheit, M. J., Becker, G. W.

Journal:

Journal of Biomolecular Screening

Year:

2015

Language:

english

File:

PDF, 475 KB

english, 2015

37

Membrane Interactions, Ligand-Dependent Dynamics, and Stability of Cytochrome P4503A4 in Lipid Nanodiscs

Treuheit, Nicholas A., Redhair, Michelle, Kwon, Hyewon, McClary, Wynton D., Guttman, Miklos, Sumida, John P., Atkins, William M.

Journal:

Year:

2016

Language:

english

File:

PDF, 8.64 MB

english, 2016

38

Das unklare Koma: effiziente Diagnostik und Therapieoptionen

Treuheit, Tim-Oliver

Journal:

Kardiologie up2date

Year:

2010

Language:

german

File:

PDF, 544 KB

german, 2010

39

Thrombomodulin Binding Selects the Catalytically Active Form of Thrombin

Handley, Lindsey D., Treuheit, Nicholas A., Venkatesh, Varun J., Komives, Elizabeth A.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.81 MB

english, 2015

40

Analysis of the five glycosylation sites of human α 1 -acid glycoprotein

Treuheit, M J, Costello, C E, Halsall, H B

Journal:

Biochemical Journal

Year:

1992

Language:

english

File:

PDF, 1.31 MB

english, 1992

41

Top-down N-terminal sequencing of Immunoglobulin subunits with electrospray ionization time of flight mass spectrometry

Da Ren, Gary D. Pipes, David Hambly, Pavel V. Bondarenko, Michael J. Treuheit, Himanshu S. Gadgil

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 6.07 MB

english, 2009

42

Asparagine-linked Oligosaccharides Present on a Non-consensus Amino Acid Sequence in the CH1 Domain of Human Antibodies

Valliere-Douglass, J. F., Kodama, P., Mujacic, M., Brady, L. J., Wang, W., Wallace, A., Yan, B., Reddy, P., Treuheit, M. J., Balland, A.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 3.39 MB

english, 2009

43

Control of Antibody Impurities Induced by Riboflavin in Culture Media During Production

Wallace, Alison, Trimble, Stephen, Valliere-Douglass, John F., Allen, Martin, Eakin, Catherine, Balland, Alain, Reddy, Pranhitha, Treuheit, Michael J.

Journal:

Journal of Pharmaceutical Sciences

Year:

2019

Language:

english

File:

PDF, 563 KB

english, 2019

44

Beidseitige Läsion des Ramus profundus nervi radialis

Treuheit, T., Diete, S., Schneider, W., Feistner, H.

Journal:

Aktuelle Neurologie

Year:

1996

Language:

german

File:

PDF, 196 KB

german, 1996

45

Structural Changes and Aggregation Mechanisms of Two Different Dimers of an IgG2 Monoclonal Antibody

Zhang, Jun, Woods, Christopher, He, Feng, Han, Mei, Treuheit, Michael J., Volkin, David B.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.21 MB

english, 2018

46

Ethanol-sodium chloride-phosphate mobile phase for size-exclusion chromatography of poly(ethylene glycol) modified proteins

Joseph J. Ratto, Sheila R. O'Conner, Adrian R. Distler, Gay-May Wu, David Hummel, Michael J. Treuheit, Alan C. Herman, Janice M. Davis

Journal:

Journal of Chromatography A

Year:

1997

Language:

english

File:

PDF, 448 KB

english, 1997

47

Inverse Relationship of Protein Concentration and Aggregation

Michael J. Treuheit, Andrew A. Kosky, David N. Brems

Journal:

Pharmaceutical Research

Year:

2002

Language:

english

File:

PDF, 191 KB

english, 2002

48

Restricted variation in the glycosylation of human α1-acid glycoprotein

M. J. Treuheit, H. B. Halsall

Journal:

Chromatographia

Year:

1993

Language:

english

File:

PDF, 390 KB

english, 1993

49

Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints

Clark, Nicholas J., Zhang, Hailiang, Krueger, Susan, Lee, Hyo Jin, Ketchem, Randal R., Kerwin, Bruce, Kanapuram, Sekhar R., Treuheit, Michael J., McAuley, Arnold, Curtis, Joseph E.

Journal:

Journal of Physical Chemistry B

Year:

2013

Language:

english

File:

PDF, 1.65 MB

english, 2013

50

Effects of Sucrose and Benzyl Alcohol on GCSF Conformational Dynamics Revealed by Hydrogen Deuterium Exchange Mass Spectrometry

Zhang, Jun, Banks, Douglas D., He, Feng, Treuheit, Michael J., Becker, Gerald W.

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 768 KB

english, 2015

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